html[data-reader]{scroll-padding-top:100px}html[data-reader] body.paper{color:#111;--ink:#111;--paper-tone:#343b46;--muted:#58616b;--faint:#58616b;--signal-blue:#0016cb;--body:"Inter",sans-serif;--display:"Chakra Petch",sans-serif;background:#f4f4f4}html[data-reader] .paper__main{grid-template-columns:230px minmax(0,1fr);align-items:start;gap:48px;max-width:1440px;margin:auto;padding:56px 4vw 80px;display:grid}html[data-reader] .paper__article{width:100%;min-width:0;max-width:none;box-shadow:none;background:0 0;border:0;margin:0;padding:0;overflow:visible}html[data-reader] .paper__title{letter-spacing:-.035em;overflow-wrap:anywhere;max-width:25ch;font:500 clamp(2.3rem,4vw,4.5rem)/1.12 Chakra Petch,sans-serif}html[data-reader] .paper__body{font:400 17px/1.8 Inter,sans-serif}html[data-reader] .paper__body :-webkit-any(h2,h3,h4){letter-spacing:-.02em;font-family:Chakra Petch,sans-serif}html[data-reader] .paper__body :is(h2,h3,h4){letter-spacing:-.02em;font-family:Chakra Petch,sans-serif}html[data-reader] .paper__body h2{margin-top:56px;font-size:clamp(1.6rem,2.4vw,2.35rem);line-height:1.25}html[data-reader] .paper__body :-webkit-any(p,li){max-width:80ch}html[data-reader] .paper__body :is(p,li){max-width:80ch}html[data-reader] :-webkit-any(pre,code,dd,td){overflow-wrap:anywhere}html[data-reader] :is(pre,code,dd,td){overflow-wrap:anywhere}html[data-reader] pre{background:#fff;border-color:#c3c8d2;max-width:100%;overflow:auto}html[data-reader] pre,html[data-reader] pre code,html[data-reader=founder] code,html[data-reader=notes] th code{color:#343b46}html[data-reader=publication] .publication-abstract__note,html[data-reader=publication] .publication-abstract__note a{color:#58616b;opacity:1}html[data-reader=publication] .publication-author a{text-underline-offset:4px;text-decoration:underline}html[data-reader] .reader-definition-note{font:inherit;margin:0}html[data-reader] :-webkit-any(pre,table):focus-visible{outline-offset:4px;outline:2px solid #5972ff}html[data-reader] :is(pre,table):focus-visible{outline-offset:4px;outline:2px solid #5972ff}html[data-reader] .paper__body table{max-width:100%}html[data-reader] .paper__body blockquote{background:#fff;border-left:3px solid #0016cb;padding:20px 24px}html[data-reader] [id]{scroll-margin-top:110px}html[data-reader] main :-webkit-any(a,button,summary):focus-visible{outline-offset:4px;outline:2px solid #5972ff}html[data-reader] main :is(a,button,summary):focus-visible{outline-offset:4px;outline:2px solid #5972ff}.reader-index{color:#111;border-top:3px solid #0016cb;min-width:0;padding-top:20px;font:13px/1.6 Inter,sans-serif;position:sticky;top:110px}.reader-index a{color:#58616b;overflow-wrap:anywhere;padding:7px 0;text-decoration:none;display:block}.reader-index a:hover,.reader-index a[aria-current]{color:#0016cb;text-underline-offset:4px;text-decoration:underline}.reader-index .reader-index__back{color:#0016cb;font-weight:500}.reader-index details{border-block-start:1px solid #c3c8d2;border-block-end:1px solid #c3c8d2;margin:20px 0;padding:16px 0}.reader-index summary{cursor:pointer;color:#111;font-weight:600}.reader-index nav{max-height:55vh;margin-top:16px;padding-right:12px;overflow:auto}.reader-index__verify{font-size:12px}html[data-reader=trials] .trial-hero{color:#111;background:#f4f4f4;border-bottom:1px solid #c3c8d2;padding:48px 4vw}html[data-reader=trials] .trial-hero__title{color:#111;max-width:25ch;font:500 clamp(2.3rem,4.4vw,4.8rem)/1.1 Chakra Petch,sans-serif}html[data-reader=trials] .trial-hero__measure{background:#fff}html[data-reader=trials] .trial-hero :-webkit-any(p,span,small,code,strong,a){color:#343b46}html[data-reader=trials] .trial-hero :is(p,span,small,code,strong,a){color:#343b46}html[data-reader=trials] .trial-hero__eyebrow a{color:#0016cb}html[data-reader=trials] .trial-hero__state{color:#704300;background:#fff0d5;border-color:#a56b11}html[data-reader=trials] .trial-hero__state--complete{color:#064e3b;background:#d8f7e8;border-color:#187c5d}html[data-reader=trials] .trial-dist__axis span{opacity:1}html[data-reader=trials] .trial-hero__figure{padding:24px}html[data-reader=trials] .trial-dist__ticks{stroke:#58616b}html[data-reader=trials] .trial-dist__ticks line{stroke:#87909e}html[data-reader=trials] .trial-dist__zero{stroke:#58616b}html[data-reader=trials] .trial-dist__median{stroke:#0016cb}html[data-reader=trials] .trial-dist__here{stroke:#a94700}html[data-reader=trials] .trial-dist__dot{fill:#a94700}html[data-reader=trials] .trial-dist__swatch--here{background:#a94700}html[data-reader=trials] .trial-dist__swatch--median{background:#0016cb}html[data-reader=trials] .trial-dist__swatch--zero{background:#58616b}html[data-reader=trials] .trial-dist__plot{background:#fff}html[data-reader=trials] .trial-dist strong{color:#111}html[data-reader] main:not(.paper__main)>.reader-index{background:#f4f4f4;flex-wrap:wrap;align-items:start;gap:32px;margin:24px 4vw;padding:16px 0;display:flex;position:static}html[data-reader] main:not(.paper__main)>.reader-index details{border:0;flex:1;min-width:230px;margin:0;padding:0}html[data-reader] main:not(.paper__main)>.reader-index nav{max-height:220px}html[data-reader] :-webkit-any(.eng-hero,.founder-hero,.dev-hero){min-height:0;padding-block-start:56px;padding-block-end:56px}html[data-reader] :is(.eng-hero,.founder-hero,.dev-hero){min-height:0;padding-block-start:56px;padding-block-end:56px}html[data-reader] :-webkit-any(.eng-hero,.founder-hero,.dev-hero) h1{max-width:24ch;font:500 clamp(2.7rem,4.8vw,5rem)/1.1 Chakra Petch,sans-serif}html[data-reader] :is(.eng-hero,.founder-hero,.dev-hero) h1{max-width:24ch;font:500 clamp(2.7rem,4.8vw,5rem)/1.1 Chakra Petch,sans-serif}html[data-reader] :-webkit-any(.eng-section,.founder-section,.dev-section){padding-block-start:60px;padding-block-end:60px}html[data-reader] :is(.eng-section,.founder-section,.dev-section){padding-block-start:60px;padding-block-end:60px}html[data-reader=publication] .publication-hero{min-height:0;padding:56px 4vw}html[data-reader=publication] .publication-hero h1{max-width:30ch;font:500 clamp(2.4rem,4.5vw,4.5rem)/1.12 Chakra Petch,sans-serif}html[data-reader=notes] .note{max-width:960px;margin:auto;padding:48px 4vw}html[data-reader=notes] .note-body{font:400 17px/1.8 Inter,sans-serif}html[data-reader=notes] .note-body :-webkit-any(h2,h3){font-family:Chakra Petch,sans-serif;line-height:1.25}html[data-reader=notes] .note-body :is(h2,h3){font-family:Chakra Petch,sans-serif;line-height:1.25}@media (max-width:1000px){html[data-reader] .paper__main{grid-template-columns:minmax(0,1fr);gap:32px;padding:28px 24px 56px}.reader-index{position:static}.reader-index nav{max-height:240px}.reader-index details{margin:12px 0;padding:12px 0}html[data-reader] .paper__title{font-size:clamp(2rem,6vw,3.5rem)}html[data-reader] .paper__body{font-size:16px;line-height:1.75}html[data-reader] .trial-hero{padding-inline-start:24px;padding-inline-end:24px}}@media print{html[data-reader] .paper__main{padding:0;display:block}.reader-index{display:none}}html[data-reader=open] .open-hero,html[data-reader=progress] .hero{color:#111;--paper:#111;--paper-dim:#343b46;--grey-700:#58616b;--signal:#0016cb;background:#f4f4f4;min-height:0;padding:48px 4vw}html[data-reader=open] .open-hero:after,html[data-reader=progress] .hero:after{display:none}html[data-reader] :-webkit-any(.open-hero__ghost,.hero__ghost){display:none}html[data-reader] :is(.open-hero__ghost,.hero__ghost){display:none}html[data-reader=open] .hero__body,html[data-reader=progress] .hero__body{flex-direction:column;align-items:flex-start;gap:24px;display:flex}html[data-reader=open] .hero__word,html[data-reader=progress] .hero__word{max-width:22ch;margin:0;font:500 clamp(3rem,5vw,5rem)/1.08 Chakra Petch,sans-serif}html[data-reader=progress] .hero__sub{letter-spacing:normal;color:#343b46;align-self:flex-start;width:auto;max-width:76ch;margin:0;font:400 18px/1.7 Inter,sans-serif;position:static}html[data-reader=open] :-webkit-any(.open-hero__lede,.hero__sub){letter-spacing:normal;color:#343b46;align-self:flex-start;width:auto;max-width:76ch;margin:0;font:400 18px/1.7 Inter,sans-serif;position:static}html[data-reader=open] :is(.open-hero__lede,.hero__sub){letter-spacing:normal;color:#343b46;align-self:flex-start;width:auto;max-width:76ch;margin:0;font:400 18px/1.7 Inter,sans-serif;position:static}html[data-reader=open] .open-hero__lede:before{display:none}html[data-reader=open] body .open-hero .hero__body .hero__sub,html[data-reader=progress] body .hero .hero__body .hero__sub{align-self:flex-start}html[data-reader=open] .hero__status,html[data-reader=progress] .hero__status{color:#343b46;background:#fff;width:-moz-fit-content;width:fit-content;margin:0 0 28px;position:static}html[data-reader=open] .hero__scroll,html[data-reader=progress] .hero__scroll{color:#0016cb;margin-top:24px;display:inline-flex;position:static}@media (max-width:760px){html[data-reader=measurements] .measure__row{grid-template-columns:1fr;gap:8px;padding-block-start:16px;padding-block-end:16px}html[data-reader=open] .open-hero,html[data-reader=progress] .hero{padding:36px 24px}html[data-reader] main:not(.paper__main)>.reader-index{gap:16px;padding:16px}}